Developmental Genome Regulation

Building a living organism requires the precise coordination of thousands of genes across space and time. We investigate the mechanisms of genome regulation that make this possible, and how their disruption contributes to human disease.

publications

Spatial patterning of the epigenome during vertebrate gastrulation

TGF-β signaling controls neural crest developmental plasticity via SMAD2/3

Changes in cellular composition shape the inductive properties of Hensen's Node

Histone lactylation couples cellular metabolism with developmental gene regulatory networks

Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells

Post-transcriptional tuning of FGF signaling mediates neural crest induction

Metabolic Reprogramming Promotes Neural Crest Migration via Yap/Tead Signaling

The connectome of neural crest enhancers reveals regulatory features of signaling systems

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